Kowalski ester homologation

The Kowalski ester homologation is a chemical reaction for the homologation of esters.^[1][2]

This reaction was designed as a safer alternative to the Arndt-Eistert synthesis. The Kowalski reaction is named after its inventor, Conrad J. Kowalski.

Additional recommended knowledge

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Reaction mechanism

The mechanism is disputed.

Variations

A modification of the procedure has been described that results in higher yields.^[3]

By changing the reagent in the second step of the reaction, the Kowalski ester homologation can also be used for the preparation of silyl ynol ethers.^{[citation needed]}

References

See also

• Curtius rearrangement