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KetolidesKetolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. These modifications give ketolides much broader spectrum than other macrolides. Moreover, ketolides are effective against macrolide-resistant bacteria, due to their ability to bind at two sites at the bacterial ribosome. Keytolides block protein synthesis by binding to ribosomal subunits and may also inhibit the formation of newly forming ribosomes. Additional recommended knowledgeThe only ketolide on the market at this moment is telithromycin, which is sold under the brand name of Ketek. Another promising ketolide is cethromycin.
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ketolides". A list of authors is available in Wikipedia. |