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Keratin 14

keratin 14
Identifiers
Symbol	KRT14
Alt. Symbols	EBS3, EBS4
Entrez	3861
HUGO	6416
OMIM	148066
RefSeq	NM_000526
UniProt	P02533
Other data
Locus	Chr. 17 q12-q21

Keratin 14 is a type I cytokeratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells.

Additional recommended knowledge

Essential Laboratory Skills Guide

Daily Visual Balance Check

Daily Sensitivity Test

Pathology

Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex and Dermatopathy Pigmentosa Reticularis, both of which are autosomal dominant mutations ^[1].

v • d • e Protein: fibrous proteins
Collagen	Type-I (COL1A1) - Type-II (COL2A1) - Type-III - Type-IV - Type-V - Type XI (COL11A2) - Type-XVII - Type-XVIII
Keratin/Cytokeratin	type I (10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), type II (1, 2A, 3, 4, 5, 6A, 7, 8, 9), Hair (Type I, Type II), Beta
other	Elastin - Cytoskeletal

References

^ Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT14. Am J Hum Genet. 2006 Oct;79(4):724-30.

Category: Keratins