Keratin 14

Keratin 14 is a type I cytokeratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells.

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Pathology

Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex and Dermatopathy Pigmentosa Reticularis, both of which are autosomal dominant mutations ^[1].

References

1. ^ Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT14. Am J Hum Genet. 2006 Oct;79(4):724-30.