Jacqueline Barton

Professor Jacqueline K. Barton is the Arthur and Marian Hanisch Memorial professor of Chemistry at California Institute of Technology. The primary focus of her research is transverse electron transport along double-stranded DNA, its implications in the biology of DNA damage and repair, and its potential for materials sciences applications. She is married to fellow Caltech chemist Peter Dervan.

Additional recommended knowledge

Daily Visual Balance Check

Recognize and detect the effects of electrostatic charges on your balance

Guide to balance cleaning: 8 simple steps

Education

Barton received her B.A. (summa cum laude) from Barnard College in 1974. She went on to graduate study at Columbia University, where she studied inorganic chemistry under the supervision of S.J. Lippard. After earning her Ph.D. from Columbia in 1979, she held post-doctoral appointments at Bell Labs and Yale University, where she worked with R.G. Shulman.

Career

At the end of her post-doc at Yale, Barton became an assistant professor of chemistry and biochemistry at Hunter College. In 1983, she joined the faculty of Columbia's chemistry department, becoming a full professor in 1986.

In the fall of 1989, Barton joined the Caltech faculty. In 1997 she became the Arthur and Marion Hanisch Memorial Professor.

Selected publications

• Gorodetsky, A.A.; A.K. Boal, and J.K. Barton (2006). "Direct Electrochemistry of Endonuclease III in the Presence and Absence of DNA". J. Am. Chem. Soc. 128: 12082-12083.

• Gorodetsky, A.A.; J.K. Barton (2006). "Electrochemistry Using Self-Assembled DNA Monolayers on Highly Oriented Pyrolytic Graphite". Langmuir 22: 7917-7922.

• Brunner, J.; J.K. Barton (2006). "Site-Specific DNA Photocleavage by Rhodium Intercalators Analyzed by MALDI-TOF Mass Spectrometry". J. Am. Chem. Soc. 128: 6772-6773.

• Yavin, E.; E.D.A. Stemp, V.L. O'Shea, S.S. David and J.K. Barton (2006). "Electron Trap for DNA-bound Repair Enzymes: A Strategy For DNA-mediated Signaling". Proc. Nat. Acad. Sci. USA 103: 3610-3614.

• Zeglis, B.M.; J.K. Barton (2006). "A Mismatch-Selective Bifunctional Rhodium-Oregon Green Conjugate: A Fluorescent Probe for Mismatched DNA". J. Am. Chem. Soc. 128: 5654-5655.

• Shao, F.; K. Augustyn and J.K. Barton (2005). "Sequence Dependence of Charge Transport through DNA Domains". J. Am. Chem. Soc. 127: 17445-17452.

• Lu, W.; D.A. Vicic, and J.K. Barton (2005). "Reductive and Oxidative DNA Damage by Photoactive Platinum(II) Intercalators". Inorg. Chem. 44: 7970-7980.

• Takada, T.; J.K. Barton (2005). "DNA Charge Transport Leading to Disulfide Bond Formation". J. Am. Chem. Soc. 127: 12204-12205.

• DeRosa, M.C.; A. Sancar, and J.K. Barton (2005). "Electrochemically Monitoring DNA Repair by Photolyase". Proc. Nat. Acad. Sci. USA 102: 10788-10792.

• O'Neill, M.A.; J.K. Barton (2005). "Sequence-Dependent DNA Dynamics: The Regulator of DNA-Mediated Charge Transport", in ed. H.A. Wagenknecht: Charge Transfer in DNA: From Mechanism to Application. Wiley-VCH, 27-75. 

• Liu, T.; J.K. Barton (2005). "DNA Electrochemistry through the Base Pairs Not the Sugar-Phosphate Backbone". J. Am. Chem. Soc. 127: 10160-10161.

• Boal, A.K.; E. Yavin, O.A. Lukianova, V.L. O'Shea, S.S. David, and J.K. Barton (2005). "DNA-Bound Redox Activity of DNA Repair Glycosylases Containing [4Fe-4S Clusters]". Biochem. 44: 8397-8407.

• Boal, A.K.; J.K. Barton (2005). "Electrochemical Detection of Lesions in DNA". Bioconj. Chem. 16: 312-321.

• Yavin, E.; A.K. Boal, E.D.A. Stemp, E.M. Boon, A.L. Livingston, V.L. O'Shea, S.S. David, and J.K. Barton (2005). "Protein-DNA Charge Transport: Redox Activation of a DNA Repair Protein by Guanine Radical". Proc. Nat. Acad. Sci. USA 102: 3546-3551.