Ivanov reaction

The Ivanov reaction is the chemical reaction of the dianions of aryl acetic acids (Ivanov reagents) with electrophiles, primarily carbonyl compounds or isocyanates.^[1][2][3][4] The reaction was named after the Bulgarian organic chemist, Dimitar Ivanov Popov, who discovered it.

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Ivanov reagents (dianions of aryl acetic acids) with react with many electrophiles, including aldehydes, ketones, isocyanates, and alkyl halides.^[5] The product does not usually spontaneously decarboxylate, but it is possible with some reagents.

The Ivanov reaction is known to proceed through the Zimmerman-Traxler model transition state. Toulec et al. have investigated the reaction rates and kinetics.^[6]

References

1. ^  Ivanov, D.; Spassoff, A. Bull. Soc. Chim. France 1931, 49, 19 & 375.
2. ^  Ivanov, D. et al. Bull. Soc. Chim. France 1932, 51, 1321 & 1325 & 1331.
3. ^  Blagoev, B.; Ivanov, D. Synthesis 1970, 615-627. (Review)
4. ^  Ivanov, D. Synthesis 1975, 83-98. (Review)
5. ^  Hauser, C. R.; Dunnavant, W. R. (1960). "α,β-Diphenylpropionic acid". Organic Syntheses 40: 38.
6. ^  Toullec, J.; Mladenova, M.; Gaudemar-Bardone, F.; Blagoev, B. J. Org. Chem. 1985, 50, 2563.

See also

• Aldol reaction