My watch list

Apraclonidine


Apraclonidine
Systematic (IUPAC) name
2,6-dichloro-N- (4,5-dihydro-1H-imidazol-2-yl) benzene-1,4-diamine
Identifiers
CAS number	66711-21-5
ATC code	S01EA03
PubChem	2216
DrugBank	APRD00012
Chemical data
Formula	C₉H₁₀Cl₂N₄
Mol. mass	245.108 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	98.7%
Metabolism	?
Half life	8 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Ophthalmic solution

Apraclonidine (INN), also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an α₂-adrenergic agonist.

Additional recommended knowledge

Guide to balance cleaning: 8 simple steps

Recognize and detect the effects of electrostatic charges on your balance

Weighing the right way

Apraclonidine is administered at a concentration of 1% for the prevention and treatment of postsurgical intraocular pressure elevation and 0.5% for short-term adjunctive therapy in patients on maximally tolerated medical therapy who require additional redirection of intraocular pressure. One drop is usually added one hour prior to laser eye surgery and another drop is given after the procedure is complete.

v • d • e Ophthalmologicals: antiglaucoma preparations and miotics (S01E)
Sympathomimetics	Apraclonidine • Brimonidine • Clonidine • Dipivefrine • Epinephrine
Parasympathomimetics	Aceclidine • Acetylcholine • Carbachol • Demecarium • Echothiophate • Stigmine (Fluostigmine, Neostigmine, Physostigmine) • Paraoxon • Pilocarpine
Carbonic anhydrase inhibitors	Acetazolamide • Brinzolamide • Diclofenamide • Dorzolamide • Methazolamide
Beta blocking agents	Befunolol • Betaxolol • Carteolol • Levobunolol • Metipranolol • Timolol
Prostaglandin analogues	Bimatoprost • Latanoprost • Travoprost • Unoprostone
Other agents	Dapiprazole • Guanethidine