Name | Source | Function
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IL-1 | macrophages | small amounts induce acute phase reaction, large amounts induce fever.
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IL-2 | TH1-cells | stimulates growth and differentiation of T cell response. Can be used in immunotherapy to treat cancer or suppressed for transplant patients.
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IL-3 | T cells | stimulates bone marrow stem cells
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IL-4 | TH2-cells, just activated naive CD4+ cell, memory CD4+ cells | involved in proliferation of B cells and the development of T cells and mast cells. Important role in allergic response (IgE)
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IL-5 | TH2-cells | role in differentiation of B cells, eosinophil production, and IgA production
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IL-6 | macrophages, TH2-cells | induces acute phase reaction
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IL-7 | stromal cells of the red marrow and thymus | involved in B, T, and NK cell survival, development, and homeostasis
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IL-8 | macrophages, epithelial cells, endothelial cells | Neutrophil chemotaxis
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IL-9 | T-cells, specifically by CD4+ helper cells | stimulates mast cells
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IL-10 | monocytes, TH2-cells, mast cells | inhibits Th1 cytokine production
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IL-11 | bone marrow stroma | acute phase protein production
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IL-12 | macrophages | NK cell stimulation, Th1 cells induction. May suppress food allergies
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IL-13 | TH2-cells | Stimulates growth and differentiation of B-Cells (IgE), inhibits TH1-cells and the production of macrophage inflammatory cytokines
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IL-14 | T cells and certain malignant B cells | controls the growth and proliferation of B cells
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IL-15 | mononuclear phagocytes (and some other cells) following infection by virus(es). | Induces production of Natural Killer Cells
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IL-16 | a variety of cells (including lymphocytes and some epithelial cells) | chemoattracts immune cells expressing the cell surface molecule CD4
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IL-17 | - | Induces production of inflammatory cytokines
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IL-18 | macrophages | Induces production of Interferon-gamma (IFNγ)
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IL-19 | | -
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IL-20 | - | regulates proliferation and differentiation of keratinocytes
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IL-21 | - |
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IL-22 | - | Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum amyloid A, Alpha 1-antichymotrypsin and haptoglobin in hepatoma cell lines
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IL-23 | - | Increases angiogenesis but reduces CD8 T-cell infiltration
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IL-24 | - | Plays important roles in tumor suppression, wound healing and psoriasis by influencing cell survival.
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IL-25 | - | Induces the production IL-4, IL-5 and IL-13, which stimulate eosinophil expansion
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IL-26 | - | Enhances secretion of IL-10 and IL-8 and cell surface expression of CD54 on epithelial cells
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IL-27 | - | Regulates the activity of B lymphocyte and T lymphocytes
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IL-28 | - | Plays a role in immune defense against viruses
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IL-29 | - | Plays a role in host defenses against microbes
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IL-30 | - | Forms one chain of IL-27
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IL-31 | - | May play a role in inflammation of the skin
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IL-32 | - | Induces monocytes and macrophages to secrete TNF-α, IL-8 and CXCL2
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IL-33 | - | Induces helper T cells to produce type 2 cytokines
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