| Interleukin 7
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| Identifiers
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| Symbol(s)
| IL7; IL-7
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| External IDs
| OMIM: 146660 MGI: 96561 Homologene: 680
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| Gene Ontology
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| Molecular Function:
| • interleukin-7 receptor binding
• protein binding
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| Cellular Component:
| • extracellular region
• extracellular space
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| Biological Process:
| • immune response
• humoral immune response
• cell-cell signaling
• positive regulation of cell proliferation
• organ morphogenesis
• positive regulation of B cell proliferation
• negative regulation of apoptosis
• bone resorption
• positive regulation of T cell differentiation
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|
| RNA expression pattern
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Additional recommended knowledge
More reference expression data
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| Orthologs
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|
| Human
| Mouse
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| Entrez
| 3574
| 16196
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| Ensembl
| ENSG00000104432
| ENSMUSG00000040329
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| Uniprot
| P13232
| Q3UT18
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| Refseq
| NM_000880 (mRNA)
NP_000871 (protein)
| NM_008371 (mRNA)
NP_032397 (protein)
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| Location
| Chr 8: 79.81 - 79.88 Mb
| Chr 3: 7.56 - 7.59 Mb
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| Pubmed search
| [1]
| [2]
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Interleukin 7 (IL7) is a hematopoietic growth factor secreted by the stromal cells of the red marrow and thymus capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis (From UniProt IL7_HUMAN).
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.[1]
References
- ^ Entrez Gene: IL7 interleukin 7.
Further reading
- Terry J. Fry and Crystal L. Mackall, "Interleukin-7: from bench to clinic", Blood, Vol. 99, No. 11, pp. 3892-3904. Review article (1 June 2002)
- Möller P, Böhm M, Czarnetszki BM, Schadendorf D (1997). "Interleukin-7. Biology and implications for dermatology.". Exp. Dermatol. 5 (3): 129-37. PMID 8840152.
- Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis.". Cytokines Cell. Mol. Ther. 5 (1): 25-39. PMID 10390077.
- Fry TJ, Mackall CL (2002). "Interleukin-7: from bench to clinic.". Blood 99 (11): 3892-904. PMID 12010786.
- Fry TJ, Mackall CL (2003). "Interleukin-7 and immunorestoration in HIV: beyond the thymus.". J. Hematother. Stem Cell Res. 11 (5): 803-7. doi:10.1089/152581602760404603. PMID 12427286.
- Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.". Histol. Histopathol. 18 (3): 911-23. PMID 12792903.
- Aspinall R, Henson S, Pido-Lopez J, Ngom PT (2004). "Interleukin-7: an interleukin for rejuvenating the immune system.". Ann. N. Y. Acad. Sci. 1019: 116-22. doi:10.1196/annals.1297.021. PMID 15247003.
- Snyder KM, Mackall CL, Fry TJ (2007). "IL-7 in allogeneic transplant: clinical promise and potential pitfalls.". Leuk. Lymphoma 47 (7): 1222-8. doi:10.1080/10428190600555876. PMID 16923550.
- Brunton LL, Lupton SD (1990). "An STS in the human IL7 gene located at 8q12-13.". Nucleic Acids Res. 18 (5): 1315. PMID 2320434.
- Lupton SD, Gimpel S, Jerzy R, et al. (1990). "Characterization of the human and murine IL-7 genes.". J. Immunol. 144 (9): 3592-601. PMID 2329282.
- Goodwin RG, Lupton S, Schmierer A, et al. (1989). "Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells.". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 302-6. PMID 2643102.
- Sutherland GR, Baker E, Fernandez KE, et al. (1989). "The gene for human interleukin 7 (IL7) is at 8q12-13.". Hum. Genet. 82 (4): 371-2. PMID 2786840.
- Muegge K, Vila MP, Durum SK (1993). "Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene.". Science 261 (5117): 93-5. PMID 7686307.
- Watanabe M, Ueno Y, Yajima T, et al. (1995). "Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.". J. Clin. Invest. 95 (6): 2945-53. PMID 7769137.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- Noguchi M, Nakamura Y, Russell SM, et al. (1994). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.". Science 262 (5141): 1877-80. PMID 8266077.
- Sica D, Rayman P, Stanley J, et al. (1993). "Interleukin 7 enhances the proliferation and effector function of tumor-infiltrating lymphocytes from renal-cell carcinoma.". Int. J. Cancer 53 (6): 941-7. PMID 8473051.
- Kroemer RT, Doughty SW, Robinson AJ, Richards WG (1996). "Prediction of the three-dimensional structure of human interleukin-7 by homology modeling.". Protein Eng. 9 (6): 493-8. PMID 8862549.
- Kroemer RT, Richards WG (1997). "Homology modeling study of the human interleukin-7 receptor complex.". Protein Eng. 9 (12): 1135-42. PMID 9010926.
- Kim JH, Loveland JE, Sitz KV, et al. (1997). "Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1.". Clin. Exp. Immunol. 108 (2): 243-50. PMID 9158092.
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