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Interleukin 27

Interleukin 27
Identifiers
Symbol	IL27
Alt. Symbols	, IL30, p28
Entrez	246778
HUGO	19157
OMIM	608273
RefSeq	NM_145659
UniProt	Q6P676
Other data
Locus	Chr. 16 p11

Interleukin 27B
Identifiers
Symbol	IL27B
Alt. Symbols	EBI3
HUGO	3129
OMIM	605816
UniProt	Q14213
Other data

Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (also called IL-28).^[1] IL-27 plays an important function in regulating the activity of B and T lymphocytes.^[2] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL-27R and gp130. The gene symbol IL27 refers to the IL-30 subunit of IL-27.^[3]

Additional recommended knowledge

References

^ F. Larousserie et al., Analysis of Interleukin-27 (EBI3/p28) Expression in Epstein-Barr Virus- and Human T-Cell Leukemia Virus Type 1-Associated Lymphomas Heterogeneous Expression of EBI3 Subunit by Tumoral Cells, American Journal of Pathology, 2005, Volume 166, pages 1217-1228.
^ F. Larousserie et al., Differential Effects of IL-27 on Human B Cell Subsets. Journal of Immunology, 2006, Volume 176, pages 5890-5897.
^ http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157

v • d • e Cytokines: interleukins
IL-1 superfamily	IL-1 (IL-1Ra) - IL-18 - IL-33
IL-6 like/gp130 utilizing	IL-6 - IL-11 - IL-27 - IL-30 - IL-31
IL-10 family	IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26
Interferon type III	IL-28 - IL-29
Common γ-chain family	IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21
IL-12 family	IL-12 - IL-23 - IL-27 - IL-35
Other	IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 - IL-32