Interleukin 25

Interleukin-25 (IL-25) is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells.^[1] It is also known as IL-17E.^[2] IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut^[3] and has been implicated in chronic inflammation associated with the gastrointestinal tract. Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.^[4]

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References

1. ^ Kei Ikeda et al., Mast cells produce interleukin-25 upon FcRI-mediated activation, Blood, 2003, Volume 101, pages 3594-3596.
2. ^ The HGNC site for IL-25
3. ^ Owyang et al., Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract, Journal of Experimental Medicine, 2006, Volume 203, 843-849.
4. ^ Buning et al., The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease. European Journal of Immunogenetics, 2003, Volume 30, pages 329-333

Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion, http://www.jem.org/cgi/content/abstract/203/4/1105