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Interleukin 24
Additional recommended knowledgeInterleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells [1] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.[2] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.[3][4] The gene for IL-24 is located on chromosome 1 in humans.[5]
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_24". A list of authors is available in Wikipedia. |