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Interleukin 3

interleukin 3
Identifiers
Symbol	IL3
Entrez	3562
HUGO	6011
OMIM	147740
RefSeq	NM_000588
UniProt	P08700
Other data
Locus	Chr. 5 q23-q31

Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system.

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IL-3 stimulates the proliferation of hematopoietic pluripotent progenitor cells. It is secreted by activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.

v • d • e Cytokines: interleukins
IL-1 superfamily	IL-1 (IL-1Ra) - IL-18 - IL-33
IL-6 like/gp130 utilizing	IL-6 - IL-11 - IL-27 - IL-30 - IL-31
IL-10 family	IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26
Interferon type III	IL-28 - IL-29
Common γ-chain family	IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21
IL-12 family	IL-12 - IL-23 - IL-27 - IL-35
Other	IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 - IL-32

v • d • e Cytokines, glycoproteins: colony-stimulating factors
Numbered	Macrophage colony-stimulating factor - Granulocyte macrophage colony-stimulating factor - Granulocyte colony-stimulating factor
Unnumbered	Erythropoietin - Thrombopoietin - Interleukin 3