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Ink4



INK4 is a tumour suppressor protein. It is associated with several genes, including p16INK4a and p14ARF, and with several other proteins, like HRAS. [1] Lack of this protein has been associated with several types of cancer, including bladder and melanoma. The 'INK4' label is given to three proteins: INK4A and INK4B. These proteins act to inhibit cdk4 and cdk6 upon binding, causing the arrest of the cell cycle in G1. [2]


References

  1. ^ http://www.nature.com/nature/journal/v440/n7084/abs/nature04585.html
  2. ^ http://www.chemistry.ohio-state.edu/~tsai/tumor_suppressor.htm
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ink4". A list of authors is available in Wikipedia.
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