Indatraline

Indatraline, also known as Lu 19-005, is a nonselective monoamine reuptake inhibitor that has been shown to block the reuptake of dopamine, norepinephrine, and serotonin with effects similar to those of cocaine. However, the effects have been shown to have slower onset and longer duration than cocaine, suggesting that the compound may, along with similar compounds, be used for treatment of cocaine abuse.^[1] Research has also suggested that indatraline can be used to block the action of methamphetamine.^[2]

Additional recommended knowledge

Weighing the right way

How to quickly check pipettes?

Daily Visual Balance Check

For a more detailed discussion of indatraline pharmacology, see Indatraline pharmacology

References

1. ^ Negus SS, Brandt MR, Mello NK. "Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys." J Pharmacol Exp Ther (1999) 291(1):60-9.[1]
2. ^ Rothman, B. R. eta al, "Neurochemical Neutralization of Methamphetamine With High-Affinity Nonselective Inhibitors of Biogenic Amine Transporters: A Pharmacological Strategy for Treating Stimulant Abuse." Synapse (2000) 35:222-227.[2]