My watch list

Ifenprodil

Ifenprodil

IUPAC name	4-[2-[4-(cyclohexylmethyl)- 1-piperidinyl]-1-hydroxypropyl]phenol
Identifiers
CAS number	245-491-4
PubChem	3689
SMILES	CC(C(C1=CC=C(C=C1)O)O) N2CCC(CC2)CC3=CC=CC=C3
Properties
Molecular formula	C₂₁H₂₇NO₂
Molar mass	325.445
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Ifenprodil is a selective inhibitor of the NMDA receptor.^[1]

Additional recommended knowledge

Essential Laboratory Skills Guide

Safe Weighing Range Ensures Accurate Results

Recognize and detect the effects of electrostatic charges on your balance

References

^ Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758-65. PMID 2555674.

NMDA receptors are multimeric ionotropic glutamate receptors composed of likely four subunits. NR1 is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.

Categories: NMDA receptor antagonists | Piperidines | Phenols