Idursulfase

Idursulfase (brand name Elaprase) is a drug used to treat Hunter syndrome (also called Mucopolysaccharoidosis II).^[1] It is a purified form of the lysosomal enzyme iduronate-2-sulfatase and is produced by recombinant DNA technology in a human cell line.

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It is one of the most expensive drugs ever produced. Initial yearly costs were reported to be $300,000.^[2]

It is manufactured by Shire Pharmaceuticals Group.

References

1. ^ Garcia AR, DaCosta JM, Pan J, Muenzer J, Lamsa JC (2007). "Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II". Mol. Genet. Metab. 91 (2): 183-90. doi:10.1016/j.ymgme.2007.03.003. PMID 17459751.
2. ^ Drug approved to treat rare but potentially deadly disease. Retrieved on 2007-09-02.