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Iclazepam


Iclazepam
Systematic (IUPAC) name
7-chloro-1-[2-(cyclopropylmethoxy)ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
Identifiers
CAS number	57916-70-8
ATC code	?
PubChem	68777
Chemical data
Formula	C₂₁H₂₁Cl N₂O₂
Mol. mass	368.857
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Iclazepam (Clazepam) is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and is around the same potency as chlordiazepoxide.

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Iclazepam is a derivative of nordazepam substituted with a cyclopropylmethoxyethyl group on the N1 nitrogen. Once in the body, iclazepam is quickly metabolised to nordazepam and its N-(2-hydroxyethyl) derivative, which are thought to be mainly responsible for its effects.^[1]

References

^ Giudicelli JF, Berdeaux A, Idrissi N, Richer C. Clazepam: pharmacokinetics and effects on performance. British Journal of Clinical Pharmacology. 1978 Jan;5(1):65-9.

v • d • e Benzodiazepines (N05BA, N05CD)
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Triazolobenzodiazepines	Adinazolam • Alprazolam • Estazolam • Triazolam • Zapizolam
Imidazobenzodiazepines	Bretazenil • Flumazenil • Imidazenil • Loprazolam • Midazolam • Ro15-4513
Oxazolobenzodiazepines	Cloxazolam • Flutazolam • Haloxazolam • Mexazolam • Oxazolam
Thienobenzodiazepines	Brotizolam • Clotiazepam • Etizolam
1,5-Benzodiazepines	Arfendazam • Clobazam • Lofendazam • Triflubazam
2,3-Benzodiazepines	Girisopam • GYKI-52895 • Nerisopam • Tofisopam
Benzodiazepine Prodrugs	Avizafone • Rilmazafone
Others	Bentazepam • Ketazolam • Tifluadom • Zolazepam