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Homotaurine

Homotaurine^[1]

IUPAC name	3-Aminopropane-1-sulfonic acid
Other names	Tramiprosate Alzhemed
Identifiers
CAS number	3687-18-1
PubChem	1646
SMILES	C(CN)CS(=O)(=O)O
Properties
Molecular formula	C₃H₉NO₃S
Molar mass	139.17346
Melting point	293 °C (decomposition)
Hazards
R-phrases	R36/37/38
S-phrases	S26 S36
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Homotaurine (also spelled homotaurin) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAnergic effects and may be useful as an anticonvulsant.^[2]

Additional recommended knowledge

Essential Laboratory Skills Guide

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Daily Sensitivity Test

Homotaurine is also being investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain.^[3]

References

^ Homotaurine at Sigma-Aldrich
^ Fariello RG, Golden GT, Pisa M (1982). "Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid". Neurology 32 (3): 241–5. PMID 7199633.
^ Aisen PS, Gauthier S, Vellas B, et al (2007). "Alzhemed: a potential treatment for Alzheimer's disease". Curr Alzheimer Res 4 (4): 473–8. PMID 17908052.