Hauptman-Woodward Medical Research Institute

The Hauptman-Woodward Medical Research Institute (HWI) is an independent, not-for-profit, biomedical research facility located in the heart of downtown Buffalo's medical campus. For half a century, HWI scientists have been committed to improving human health through study, at a molecular level, of the causes and potential cures of many diseases. In contrast to clinical research, the focus of Hauptman-Woodward’s basic research is to determine the structures of individual substances such as proteins that play a role in the development of specific diseases. This research explores questions like the following: What is the three-dimensional shape of a particular protein molecule? How and with what does this protein interact? What controls these interactions? What structural alterations lead to the development of disease?

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Working under the leadership of Nobel Laureate Herbert Hauptman, HWI scientists use the techniques of molecular biology, biochemistry, and crystallography to answer these questions. The results of their investigations provide the starting point for better drug design. In addition, other research on-going at HWI seeks to improve the methods of crystallization and data analysis used for molecular structure determination by scientists worldwide.