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Halazepam



Halazepam
Systematic (IUPAC) name
9-chloro-6-phenyl-2-(2,2,2-trifluoroethyl)-2,5-diazabicyclo [5.4.0]undeca-5,8,10,12-tetraen-3-one
Identifiers
CAS number	23092-17-3
ATC code	N05BA13
PubChem	31640
DrugBank	APRD01009
Chemical data
Formula	C₁₇H₁₂Cl F₃N₂O
Mol. mass	352.7
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	?
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule IV (US)
Routes	Oral

Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoromethyl derivative of nordazepam.^[1] While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them.^[2]

References

^ Greenblatt, D. J.; A. Locniskar and R. I. Shader (June 12, 1982). "Halazepam, another precursor of desmethyldiazepam". Lancet 1 (8285): 1358-9. PubMed.
^ Fann, W. E.; W. M. Pitts and J. C. Wheless (Mar-Apr 1982). "Pharmacology, efficacy, and adverse effects of halazepam, a new benzodiazepine". Pharmacotherapy 2 (2): 72-9. PubMed.

v • d • e Benzodiazepines (N05BA, N05CD)
1,4-Benzodiazepines	Bromazepam • Camazepam • Chlordiazepoxide • Cinolazepam • Clonazepam • Clorazepate • Cyprazepam • Delorazepam • Diazepam • Doxefazepam • Elfazepam • Ethyl loflazepate • Fletazepam • Fludiazepam • Fosazepam • Flunitrazepam • Flurazepam • Flutoprazepam • Gidazepam • Halazepam • Iclazepam • Lorazepam • Lormetazepam • Meclonazepam • Medazepam • Menitrazepam • Metaclazepam • Nimetazepam • Nitrazepam • Nordazepam • Oxazepam • Phenazepam • Pinazepam • Pivoxazepam • Prazepam • Quazepam • QH-II-66 • Reclazepam • Sulazepam • Temazepam • Tetrazepam • Uldazepam
Triazolobenzodiazepines	Adinazolam • Alprazolam • Estazolam • Triazolam • Zapizolam
Imidazobenzodiazepines	Bretazenil • Flumazenil • Imidazenil • Loprazolam • Midazolam • Ro15-4513
Oxazolobenzodiazepines	Cloxazolam • Flutazolam • Haloxazolam • Mexazolam • Oxazolam
Thienobenzodiazepines	Brotizolam • Clotiazepam • Etizolam
1,5-Benzodiazepines	Arfendazam • Clobazam • Lofendazam • Triflubazam
2,3-Benzodiazepines	Girisopam • GYKI-52895 • Nerisopam • Tofisopam
Benzodiazepine Prodrugs	Avizafone • Rilmazafone
Others	Bentazepam • Ketazolam • Tifluadom • Zolazepam

v • d • e Psycholeptics: anxiolytics (N05B)
Benzodiazepine	Adinazolam - Alprazolam - Bretazenil - Bromazepam - Camazepam - Chlordiazepoxide - Clobazam - Clorazepate - Clonazepam - Clotiazepam - Cloxazolam - Diazepam - Ethyl loflazepate - Etizolam - Fludiazepam - Halazepam - Imidazenil - Ketazolam - Lorazepam - Medazepam - Nordazepam - Oxazepam - Pinazepam - Prazepam - Tofisopam
Nonbenzodiazepine	Alpidem - Etifoxine - L-838,417 - Ocinaplon - Pagoclone - Panadiplon - Pipequaline - RWJ-51204 - Y-23684
Diphenylmethane	Hydroxyzine - Captodiame
Carbamates	Emylcamate - Carisoprodol - Mebutamate - Meprobamate - Phenprobamate - Tybamate
β-Carbolines	Abecarnil - Gedocarnil - SL-651,498
Dibenzo-bicyclo-octadiene	Benzoctamine
Azaspirodecanedione (serotonin agonist)	Buspirone - Gepirone - Tandospirone
Other	Mephenoxalone

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Halazepam". A list of authors is available in Wikipedia.