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human major histocompatibility complex, class II, DR8
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Haplotypes groups
| DQA*01:DRB1*0801 to
DQA*01:DRB1*0806
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Structure (See HLA-DR)
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Identifiers | alpha *0101
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Symbol(s)
| HLA-DRA
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EBI-HLA
| DRA*0101
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Identifiers | beta 1 *0801 to *0806
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Symbol(s)
| HLA-DRB1
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EBI-HLA
| DRB1*0801
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EBI-HLA
| DRB1*0802
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EBI-HLA
| DRB1*0803
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EBI-HLA
| DRB1*0804
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EBI-HLA
| DRB1*0805
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EBI-HLA
| DRB1*0806
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Shared data
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Locus
| chr.6 6p21.31
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HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.
Additional recommended knowledge
Serology
DR8 serological recognition of the gene products of some DRB1*08 alleles[1]
DRB1* | DR8
| Sample
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allele | % | size (N)
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0801 | 95 | 1076
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0802 | 96 | 265
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0803 | 88 | 230[2]
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0804 | 93 | 186
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0805 | >60 | 5
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0806 | >75 | 13
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The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.
Disease associations
DQ8 is linked to papillary thyroid carcinomas [3], early onset pauciarticular juvenile chronic arthritis[4][5], primary biliary cirrhosis[6]
by allele
HLA-DRB1*0801 is linked to primary biliary cirrhosis[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.[8]
HLA-DRB1*0803 is also linked to primary biliary cirrhosis[7]
Genetic Linkage
DR8 Haplotypes
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| DRA | DRB1 |
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Haplotypes
| *0101 | *0801 | *0101
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| DQA1 | DQB1 | DRB1
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Haplotypes
| *0401 | *0402 | *0801
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| HLA-A | HLA-B | DRB1
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Haplotypes
| *0000 | *0000 | *0801
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HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.
References
- ^ derived from IMGT/HLA
- ^ DR12 - 3%
- ^ Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas.". Clin Endocrinol (Oxf) 64 (2): 179-83. PMID 16430717.
- ^ Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E. "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis.". Clin Exp Rheumatol 12 Suppl 10: S7-14. PMID 7955632.
- ^ Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.". J Rheumatol 31 (11): 2281-5. PMID 15517645.
- ^ Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.". Hepatology 16 (6): 1404-8. PMID 1359995.
- ^ a b Charatcharoenwitthaya P, Lindor K. "Current concepts in the pathogenesis of primary biliary cirrhosis.". Ann Hepatol 4 (3): 161-75. PMID 16177655.
- ^ Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, et al (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". Pediatric diabetes 8 (1): 5-10. doi:10.1111/j.1399-5448.2006.00221.x. PMID 17341285.
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