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HLA-DR14


major histocompatibility complex, class II, DR14
Haplotypes groups	DRA01:DRB11401 DRA01:DRB11402 DRA01:DRB11403 DRA01:DRB11404 ....
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 1401 to 1408 *1410
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*1401
EBI-HLA	DRB1*1402
EBI-HLA	DRB1*1403
EBI-HLA	DRB1*1404
EBI-HLA	DRB1*1405
EBI-HLA	DRB1*1406
Shared data
Locus	chr.6 6p21.31

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

Additional recommended knowledge

Essential Laboratory Skills Guide

Daily Sensitivity Test

Alleles

DR14, DR6 and other serotype recognition of some DRB1*14 alleles^[1]
DRB1*	DR14	DR6	DR13	Sample
allele	%	%	%	size (N)
1401	74	14	3	1942
1402	61	13	9	204
1403	72	12	2	37
1404	79	8		80^[2]
1405	86	10		58
1406	37	15	22	117
1407	90			10
1408	25			4 ^[3]
1410	>75			4

Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462

Disease associations

DRB1*1402: juvenile rheumatoid arthritis^[4], increased longevity in Okinawans.

Extended linkage

DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.^[5]

Genetic Linkage

DR14 Haplotypes
	DRA	DRB1	DRB3
DR14(6)-DR52	*0101	*1401	*0201
	*0101	*1402	*0201
	*0101	*1403	*0101
	DQA1	DQB1	DRB1
DR14-DQ5(5.3, 1)	*0104	*0503	*1401
	HLA-A	HLA-B	DRB1
A11-B35-DR14(6)	*1101	*3501	*1401
A2-B51(5)-DR14(6)	*0201	*5101	*1401

HLA-DR13 is genetically linked to HLA-DR52^[6] and HLA-DQ5 (HLA-DQ1) serotypes.

References

^ derived from IMGT/HLA
^ DR1404 - 3%
^ DR4 - 25%
^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol 65 (4): 359-65. PMID 15120191.
^ Niks EH, Kuks JB, Roep BO, et al (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology 66 (11): 1772-4. doi:10.1212/01.wnl.0000218159.79769.5c. PMID 16769963.
^ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270-6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.