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HLA-DQ5


HLA-DQ5
Haplotypes	DQA10101:DQB10501 DQA10102:DQB10502 DQA10104:DQB10503
Structure	See: HLA-DQ
Identifiers	alpha 1 0101 0102 *0104
EBI-HLA	DQA1*0101
EBI-HLA	DQA1*0102
EBI-HLA	DQA1*0104
Identifiers	beta 1 0501 to 0504
EBI-HLA	DQB1*0501
EBI-HLA	DQB1*0502
EBI-HLA	DQB1*0503
EBI-HLA	DQB1*0504
Shared data
Locus	chr.6 6p21.31

HLA-DQ5 (DQ5) is a HLA-DQ serotype that recognizes the beta chain varaints encoded by the HLA-DQB1*05 subgroup. DQ5 is synonymous with HLA-DQB1*05. The serotype recognizes with moderate efficiency the gene products of the DQB1*0501, *0502, *0503, *0504 alleles. DQ5 is a split antigen of the older HLA-DQ1 which recognized the alpha chain of DQ.

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1 Serology
2 Disease associations
- 2.1 By serotype
- 2.2 By haplotype
3 References

Serology

DQ5, DQ1, and DQ6 recognition of some Some DQB1* alleles >^[1]
DQB1*	DQ5	DQ1	DQ6	Sample
allele	%	%	%	size (N)
0501	69	20	2	5536
0502	48	24	15	919
0503	58	22	4	1327
0504	59	17	2	48

The efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed above. Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ5 recognition is relatively low and error prone.

While DQ5 recognizes DQB1*05 alleles more efficiently than DQ1, the serotyping is rather poor method of typing for transplantation or disease association prediction or study.

Disease associations

By serotype

DQ5 is negatively associated with DQ5 Idiopathic nephrotic syndrome in Polish children, ^[2], and adrenocortical failure (Addison's disease)^[3].

A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality show DQ5 more likely^[4], AIDP type of Guillain Barré syndrome,^[5] and irritable bowel disease ^[6] but not crohn's disease in the same (jewish) population. Other studies show DQ5 is associated with extrachromosomal manifestations of Crohn's.^[7]

DQ5 appears to be associated with Analgesic intolerance^[8]

By haplotype

MuSK antibody-positive myasthenia gravis HLA-DR14-DQ5 ^[9], probably DRB1*1402:DQA1*0104:DQB1*0503. DR1-DQ5 is associated with acid anyhydride sensitivity^[10]

References

^ derived from IMGT/HLA
^ Krasowska-Kwiecień A, Sancewicz-Pach K, Moczulska A (2006). "Idiopathic nephrotic syndrome in Polish children - its variants and associations with HLA". Pediatr. Nephrol. 21 (12): 1837-46. doi:10.1007/s00467-006-0271-7. PMID 16967287.
^ Myhre AG, Undlien DE, Løvås K, et al (2002). "Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features". J. Clin. Endocrinol. Metab. 87 (2): 618-23. PMID 11836294.
^ Wang JF, Zhang D, Zhao JZ, Jia BX, Bi RM (2006). "A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality". Surgical neurology 66 Suppl 1: S25-8; discussion S28-9. doi:10.1016/j.surneu.2006.06.048. PMID 16904993.
^ Guo L, Wang W, Li C, Liu R, Wang G (2002). "[The association between HLA typing and different subtypes of Guillain Barré syndrome]" (in Chinese). Zhonghua Nei Ke Za Zhi 41 (6): 381-3. PMID 12137599.
^ Trachtenberg EA, Yang H, Hayes E, et al (2000). "HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations". Hum. Immunol. 61 (3): 326-33. PMID 10689124.
^ Hesresbach D, Alizadeh M, Bretagne JF, et al (1996). "Investigation of the association of major histocompatibility complex genes, including HLA class I, class II and TAP genes, with clinical forms of Crohn's disease". Eur. J. Immunogenet. 23 (2): 141-51. PMID 8732477.
^ Kalyoncu AF, Karakaya G, Yilmaz E, Balci B, Karaduman A, Yasavul U (2003). "Analgesic intolerance with or without bronchial asthma: is there a marker?". Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 13 (3): 162-9. PMID 14635465.
^ Niks EH, Kuks JB, Roep BO, et al (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology 66 (11): 1772-4. doi:10.1212/01.wnl.0000218159.79769.5c. PMID 16769963.
^ Jones MG, Nielsen J, Welch J, et al (2004). "Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acid anhydrides". Clin. Exp. Allergy 34 (5): 812-6. doi:10.1111/j.1365-2222.2004.1956.x. PMID 15144476.

v • d • e HLA DQ Serotypes
DQ - DQ1 - DQ2 - DQ3 - DQ4 - DQ5 - DQ6 - DQ7 - DQ8 - DQ9

Category: HLA-DQ haplotypes

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-DQ5". A list of authors is available in Wikipedia.