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HLA-B53



major histocompatibility complex (human), class I, B53
Alleles B*5301
B*5302
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5301
EBI-HLA B*5302
Locus chr.6 6p21.31

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. ((For terminology help see: HLA-serotype tutorial)

Contents

Serotype

B53 and B35 serotype recognition of Some HLA B*35 allele-group gene products[3]
B*53 B53 B35 Sample
allele % % size (N)
5301 86 5 3054
5302 80 20 5


B*5301 allele frequencies

HLA B*7801 frequencies
freq
ref. Population (%)
[4] Akan Adiopodoume (Ivory Coast)22.7
[4] Rimaibe (Burkina Faso)22.3
[4] Mossi (Burkina Faso) 20.8
[4] Bandiagara (Mali) 15.9
[4] Sawa (Cameroon)11.5
[4] Lusaka (Zambia) 10.2
[4] Baka Pygmy (Cameroon) 10.0
[4] Guinea Bissau10.0
[4] Harare Shona (Zimbabwe )9.3
[4] Baloch (Iran) 9.1
[4] Kenya 8.7
[4] Canoncito Navajo (USA)8.5
[4] Brahui (Pakistan)7.7
[4] Niokholo Mandenka (Senegal)5.3
[4] Croatia (2)5.0
[4] Mongolia Khoton Tarialan4.9
[4] Pakistan Baloch4.6
[4] Casablanca (Morocco)3.7
[4] Arratia Basque (Spain) 3.3
[4] Crete (Greece)3.2
[4] Israel Arab Druse2.5
[4] Israel Gaza Palestinians2.4
[4] Amman (Jordan )2.4
[4] Tunis (Tunisia )2.3
[4] Tuva (2) (Russia)2.2
[4] Oman2.1
[4] France South East1.6
[4] Saudi Arabia Guraiat and Hail1.5
[4] Berber (Morocco)1.4
[4] Georgia Svaneti Svans1.3
[4] Mongolia Khalkh Ulaanbaatar1.2
[4] Spain Catalonia Girona1.1
[4] India Andhra Pradesh Golla1.0
[4] Mongolia Khalha1.0

Haplotype frequencies

A*3601 : Cw*0401 : B*5301
freq
ref. Population (%)
Zimbabwe3.6
[4] Zambia Lusaka2.3
N. Afr. Negroid 2.1
[4] Kenya Luo1.9
[4] Cameroon Yaounde1.7
[5] African American1.5
[4] Kenya Nandi1.3
[5] American Hispanic0.2
'
A*6802 : Cw*0401 : B*5301
[4] Mali Bandihagara2.7
[5] African American1.4
[4] Kenya Nandi1.0
[5] Hispanic American 0.6
[5] Caucasian American 0.2

Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in african americans.

References

  1. ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. ^ Allsopp CE, Hill AV, Kwiatkowski D, et al (1991). "Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35". Hum. Immunol. 30 (2): 105–9. PMID 2022493.
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
  5. ^ a b c d e Maiers M, Gragert L, Klitz W (2007). "High-resolution HLA alleles and haplotypes in the United States population". Hum. Immunol. 68 (9): 779–88. doi:10.1016/j.humimm.2007.04.005. PMID 17869653.
v • d • e
HLA-B Serotypes and allele groups
HLA-B - B5 (B51 - B52) - B7 - B8 - B12 (B44 - B45) - B13 - B14 (B64 - B65) - B15 (B62 - B63 - B70 - B71- B75 - B76 - B77) - B16 (B38 - B39) - B17 (B57 - B58) - B18 - B21 (B49 - B50) - B22 (B54 - B55 - B56) - B27 - B35 - B37 - B40 (B60 - B61) - B41 - B42 - B46 - B47 - B48 - B53 - B59 - B67 - B73 - B78 - B81 - B*82 - B*83
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-B53". A list of authors is available in Wikipedia.
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