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HLA-A74




major histocompatibility complex (human), class I, A74
Alleles	A7401 A7403
Structure (See HLA-A)
Identifiers	7401 7403
Symbol(s)	HLA-A
EBI-HLA	A*7401
EBI-HLA	A*7403
Shared data
Locus	chr.6 6p21.31

HLA-A74 (A74) is an HLA-A serotype. The serotype identifies the HLA-A*7401 gene product. A74 is a split antigen type of the A19 broad antigen type. A74 is rare.

Additional recommended knowledge

Essential Laboratory Skills Guide

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Serotype

A74, A19 serotype recognition of Some HLA A*74 allele-group gene products^[1]
A*74	A74	A19	Sample
allele	%	%	size (N)
7401	40	11	119
7401	17		29

Disease associations

A significant association has been found between A74 and nasal polyposis.^[2]

A*74 allele Frequencies

HLA A*7401 frequencies
		freq
ref.	Population	(%)
^[3]	Kenya	9.7
^[3]	Cameroon Beti	8.3
^[3]	Guinea Bissau	7.7
^[3]	Burkina Faso Mossi	6.6
^[3]	Uganda Kampala	5.2
^[3]	Cameroon Yaounde	5.0
^[3]	Cameroon Bamileke	4.5
^[3]	Cameroon Sawa	3.8
^[3]	Mali Bandiagara	3.6
^[3]	Iran Baloch	2.8
^[3]	Zimbabwe Harare Shona	2.7
^[3]	Senegal Niokholo Mandenka	2.2
^[3]	Burkina Faso Rimaibe	2.1
^[3]	Kenya Nandi	1.7
^[3]	Morocco Nador Metalsa	1.4
^[3]	Thailand Northeast	1.2
^[3]	Thailand	1.1
^[3]	Jordon Amman	0.7
^[3]	Jordon Amman	0.5
^[3]	China South	0.5

HLA A*7403 frequencies
		freq
ref.	Population	(%)
^[3]	Kenya Luo	7.3
^[3]	Iran Baloch	0.6
^[3]	Kenya	0.3
^[3]	Uganda Kampala	0.3

References

^ derived from IMGT/HLA
^ Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). "HLA patterns in patients with nasal polyposis". European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 257 (3): 137–9. PMID 10839486.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.

v • d • e HLA-A Serotypes
HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80

Category: HLA-A alleles

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A74". A list of authors is available in Wikipedia.