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HLA-A66




major histocompatibility complex (human), class I, A66
Alleles	A6601 A6602 A*6603
Structure (See HLA-A)
Identifiers	6601 6602 6603
Symbol(s)	HLA-A
EBI-HLA	A*6601
EBI-HLA	A*6602
EBI-HLA	A*6603
Shared data
Locus	chr.6 6p21.31

HLA-A66 (A66) is an HLA-A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.^[1] A66 is more common in Africa and SW Europe. A66 is uncommon.

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Serotype

A66, A10 serotype recognition of Some HLA A*66 allele-group gene products^[2]
A*66	A66	A10	A26	Other	Sample
allele	%	%	%	%	size (N)
6601	20	10	61	3	799
6602	38	10	4	31	205
6603	32	7	7	18	28

A*6601 Frequencies

HLA A*6601 frequencies
		freq
ref.	Population	(%)
^[3]	Cameroon Sawa	7.7
^[3]	Kenya Luo	6.8
^[3]	Cameroon Sawa	7.7
^[3]	Cameroon Bakola Pygmy	5.8
^[3]	Cameroon Baka Pygmy	5.0
^[3]	Kenya Nandi	5.0
^[3]	Zimbabwe Harare Shona	0.2
^[3]	Cameroon Baka Pygmy	5.0
^[3]	Cameroon Beti	4.6
^[3]	Cameroon Bamileke	4.5
^[3]	India West Bhils	4.0
^[3]	Zimbabwe Harere Shona	3.8
^[3]	Uganda Kampala	3.8
^[3]	India Mumbia Marathas	2.5
^[3]	Cape Verde Northwestern	2.5
^[3]	Czech republic	2.4
^[3]	Morocco Nador Metalsa	2.1
^[3]	Central Portugal	2.0
^[3]	India West Parsis	2.0
^[3]	South Africian Natal Zulu	2.0
^[3]	Kenya	1.7
^[3]	Tunisia Tunis	1.7
^[3]	Guinea Bissau	1.5
^[3]	Georgia Tibilisi	1.4
^[3]	Zambia Lusaka	1.2
^[3]	Italy Bergamo	1.1
^[3]	Pakistan Karachi Parsi	1.1
^[3]	Oman	0.8
^[3]	Sudanese	0.8
^[3]	Belgium	0.5
^[3]	Southeast France	0.4
^[3]	Mongolia Buriat	0.4
^[3]	Wales	0.2

HLA A*6602 frequencies
		freq
ref.	Population	(%)
^[3]	South Africian Natal Zulu	1.5
^[3]	Cameroon Yaounde	1.1
^[3]	Cameroon Bamileke	0.6
^[3]	Senegal Niokholo Mandenka	0.5
^[3]	Kenya Nandi	0.4
^[3]	Zimbabwe Harare Shona	0.2
^[3]	Wales	0.03
HLA A*6603 frequencies
		freq
ref.	Population	(%)
^[3]	Cameroon Pygmy Baka	10.0
^[3]	Cameroon Bakola Pygmy	9.0
^[3]	Cameroon Sawa	7.7
^[3]	CAR Mbenzele Pygmy	2.8
^[3]	Zimbabwe Harare Shona	0.2

References

^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
^ derived from IMGT/HLA
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.

v • d • e HLA-A Serotypes
HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80

Category: HLA-A alleles

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A66". A list of authors is available in Wikipedia.