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HLA-A66




major histocompatibility complex (human), class I, A66
Alleles	A6601 A6602 A*6603
Structure (See HLA-A)
Identifiers	6601 6602 6603
Symbol(s)	HLA-A
EBI-HLA	A*6601
EBI-HLA	A*6602
EBI-HLA	A*6603
Shared data
Locus	chr.6 6p21.31

HLA-A66 (A66) is an HLA-A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.^[1] A66 is more common in Africa and SW Europe. A66 is uncommon.

Additional recommended knowledge

Essential Laboratory Skills Guide

What is the Correct Way to Check Repeatability in Balances?

Weighing the right way

Serotype

A66, A10 serotype recognition of Some HLA A*66 allele-group gene products^[2]
A*66	A66	A10	A26	Other	Sample
allele	%	%	%	%	size (N)
6601	20	10	61	3	799
6602	38	10	4	31	205
6603	32	7	7	18	28

A*6601 Frequencies

HLA A*6601 frequencies
		freq
ref.	Population	(%)
^[3]	Cameroon Sawa	7.7
^[3]	Kenya Luo	6.8
^[3]	Cameroon Sawa	7.7
^[3]	Cameroon Bakola Pygmy	5.8
^[3]	Cameroon Baka Pygmy	5.0
^[3]	Kenya Nandi	5.0
^[3]	Zimbabwe Harare Shona	0.2
^[3]	Cameroon Baka Pygmy	5.0
^[3]	Cameroon Beti	4.6
^[3]	Cameroon Bamileke	4.5
^[3]	India West Bhils	4.0
^[3]	Zimbabwe Harere Shona	3.8
^[3]	Uganda Kampala	3.8
^[3]	India Mumbia Marathas	2.5
^[3]	Cape Verde Northwestern	2.5
^[3]	Czech republic	2.4
^[3]	Morocco Nador Metalsa	2.1
^[3]	Central Portugal	2.0
^[3]	India West Parsis	2.0
^[3]	South Africian Natal Zulu	2.0
^[3]	Kenya	1.7
^[3]	Tunisia Tunis	1.7
^[3]	Guinea Bissau	1.5
^[3]	Georgia Tibilisi	1.4
^[3]	Zambia Lusaka	1.2
^[3]	Italy Bergamo	1.1
^[3]	Pakistan Karachi Parsi	1.1
^[3]	Oman	0.8
^[3]	Sudanese	0.8
^[3]	Belgium	0.5
^[3]	Southeast France	0.4
^[3]	Mongolia Buriat	0.4
^[3]	Wales	0.2

HLA A*6602 frequencies
		freq
ref.	Population	(%)
^[3]	South Africian Natal Zulu	1.5
^[3]	Cameroon Yaounde	1.1
^[3]	Cameroon Bamileke	0.6
^[3]	Senegal Niokholo Mandenka	0.5
^[3]	Kenya Nandi	0.4
^[3]	Zimbabwe Harare Shona	0.2
^[3]	Wales	0.03
HLA A*6603 frequencies
		freq
ref.	Population	(%)
^[3]	Cameroon Pygmy Baka	10.0
^[3]	Cameroon Bakola Pygmy	9.0
^[3]	Cameroon Sawa	7.7
^[3]	CAR Mbenzele Pygmy	2.8
^[3]	Zimbabwe Harare Shona	0.2

References

^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
^ derived from IMGT/HLA
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.

v • d • e HLA-A Serotypes
HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80

Category: HLA-A alleles

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A66". A list of authors is available in Wikipedia.