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HLA-A32



major histocompatibility complex (human), class I, A32
Alleles A*3201
A*3202
A*3204
Structure (See HLA-A)
Identifiers
3201 3202 3204
Symbol(s) HLA-A
EBI-HLA A*3201
EBI-HLA A*3202
EBI-HLA A*3204
Locus chr.6 6p21.31

HLA-A32 (A32) is an HLA-A serotype. The serotype identifies the more common HLA-A*32 gene products. A32 is a split antigen of the A19 serotype group. This group also includes A29, A30, A31, A33, and A74 serotypes

Contents

Serotype

A32 serotype recognition of Some HLA A*32 allele-group gene products[1]
A*32 A32 A19 Sample
allele % % size (N)
A3201 94 3441
A3202 67 3
A3201 17 17 6

Serotyping efficiency for the predominant allele is good. There are 16 known alleles that result in 15 isoforms of HLA-A32. One isoform may be poorly expressed.[2]




HLA-A*3201 allele frequencies

HLA A*3201 frequencies
freq
ref. Population (%)
[3] Oman11.4
[3] Pakistan Brahui9.2
[3] Italy Sardinia (3)8.7
[3] Bulgaria8.2
[3] Burkina Faso Fulani8.2
[3] Pakistan Karachi Parsi7.8
[3] Pakistan Kalash7.5
[3] France South East7.2
[3] Pakistan Baloch7.1
[3] Georgia Tibilisi Kurds6.7
[3] Iran Baloch6.7
[3] Italy Bergamo5.9
[3] India North Hindus5.8
[3] Croatia5.7
[3] France Corsica5.5
[3] Sudanese5.5
[3] Pakistan Pathan5.1
[3] Pakistan Sindhi5.1
[3] Romanian5.0
[3] Cape Verde NW Islands4.8
[3] Georgia Tibilisi Georgians4.8
[3] Bulgaria Gipsy4.2
[3] Cape Verde SE Islands4.0
[3] Israel Arab Druse4.0
[3] Portugal Centre4.0
[3] Spain Majorca and Minorca3.9
[3] Burkina Faso Mossi3.8
[3] Guinea Bissau3.8
[3] Belgium3.7
[3] Cuban Mulatto3.6
[3] Cuban White3.6
[3] Australia New South Wales3.4
[3] Morocco Nador Metalsa3.4
[3] Ireland Northern3.2
[3] Jordan Amman3.1
[3] Portugal South3.1
[3] India Khandesh Pawra3.0
[3] India New Delhi3.0
[3] India West Coast Parsis3.0
[3] Azores Central Islands2.7
[3] India North Delhi2.7
[3] Pakistan Burusho2.7
[3] Kenya Luo2.6
[3] Spain Eastern Andalusia Gipsy2.6
[3] South Africian Natal Zulu2.5
[3] China North Han2.4
[3] Czech Republic2.4
[3] Mexico Mestizos2.4
[3] China Beijing2.2
[3] Finland2.2
[3] Uganda Kampala2.2
[3] Russia Tuva pop 22.1
[3] Brazil2.0
[3] Cameroon Beti2.0
[3] Cape Yk P. (Indig. Aust.)1.9
[3] Italy North pop 11.9
[3] Kenya Nandi1.9
[3] Tunisia1.5
[3] Georgia Svaneti Svans1.3
[3] New Caledonia1.2
[3] Golla (Andhra Prad. India) 1.1
[3] Senegal Niokholo Mandenka1.1
[3] Thailand1.1
[3] Cameroon Bakola Pygmy1.0
[3] China Inner Mongolia1.0
[3] Kenya 1.0
[3] Javanese (Singapore)1.0
[3] South Africa Natal Tamil1.0
[3] Basque (Gipuzkoa, Spain)1.0
[3] China Qinghai Hui0.9
[3] Tibet (china)0.9
[3] Zimbabwe Harare Shona0.9
[3] Beijing Shijiazhuang Tianjian0.8
[3] Groote Eylandt (Indig. Austr.)0.7
[3] Mali Bandiagara0.7
[3] Singapore Chinese0.7
[3] Argentina Toba Rosario0.6
[3] India Mumbai Marathas0.6
[3] Spain Catalonia Girona0.6
[3] Hong Kong Chinese0.4
[3] Yuendumu (indig. Australia)0.3
[3] Thailand Northeast 0.2

A32 is most common around the Persian Gulf and the Mediterranean Basin. It has a consistent presence in Europe. The A32 frequenceies in the more isolated (genetically) peoples of Europe suggests that the A32 rise in the Mediterranean may only be partially attributable to recent migrations from the middle eastern region. There is a node in southern Europe around the Ionian Sea in which specific, European, A32-haplotypes are elevated.

A32 Haplotypes

HLA A32 haplotype frequencies
freq
ref. Population (%)
A32-B7
(A*3201:B*0702)
Albanian 2.2
Cuban 1.9
[4] Natal Zulu (S. Africa) 1.0
Cretan 0.7
Cretan 0.2
A32-B8
(A*3201:B*0801)
N. Portugal 2.2
Oman 1.8
A32-B14
(A*3201:B*14)
!kung 1.9
Tunis 1.8
Natal Zulu (S. Africa) 1.0
Portugal 1.1
Irish 0.7
Italian 0.6
A32-B27
(A*3201:B27)
Gypsy(Spanish) 6.0
E Black Sea (Turkey) 2.3
German 0.3
A32-B35
(A*3201:C*0401:B*3501)
Greek3.5
UA Emirates2.8
Sardinian2.6
Brahui (Pakistan)2.5
Tunisia1.8
Armenian1.7
Italian1.5
Oman1.3
Portugal1.1
German0.3
A32-B61(40)
(A*3201:B*40)
Tunis1.2
Greek1.2
French0.6
German0.4
A32-B44
(A*3201:B*4402)
Austrian2.4
Belgium2.0
Albanian1.8
S. Portugal1.0
Irish0.7
German0.6
Dutch0.6
Senegal0.5
Italian0.4
A32-B51
(A*3201:C*1201:B*5101)
Bulgarian1.8
German0.3
(A*3201:C*1502:B*5101)
Oman 5.0
Baloch (Pakistan)3.2
Kalash2.9
UA Emirates1.9
Baloch (Iran)1.1
(A*3201:C*1401:B*5101)
Parsis (Karachi)4.9
Kalash2.9

A common A32 haplotype A*3201-B*5101 can be found in Oman, United Arab Emirates, SE Iran, Bulgaria, and Portugal. A second, A*3201-B*3501 can be in the Omani, UAE, and Portugal.

References

  1. ^ derived from IMGT/HLA
  2. ^ Tang TF, Hou L, Tu B, et al (2006). "Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries". Tissue Antigens 68 (6): 518–20. doi:10.1111/j.1399-0039.2006.00707.x. PMID 17176443.
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx by bz ca cb cc cd Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
  4. ^ B*0705
v • d • e
HLA-A Serotypes
HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A32". A list of authors is available in Wikipedia.
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