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HLA-A25




major histocompatibility complex (human), class I, A25
Alleles	A2501 A2502
Structure (See HLA-A)
Identifiers	2501 2502
Symbol(s)	HLA-A
EBI-HLA	A*2501
EBI-HLA	A*2502
Shared data
Locus	chr.6 6p21.31

HLA-A25 (A25) is an HLA-A serotype. The serotype identifies the more common HLA-A*25 gene products. A25 is a split antigen of the A10 broad antigen serotype group. It is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.^[1] A26 is more common in Western Europe.

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Serotype

A25 and A10 serotype recognition of HLA A*2501 allele-group gene products^[2]
A*25	A25	A10	Sample
allele	%	%	size (N)
2501	95	2	1375
2502	80		5

There are 7 alleles for A25, 6 that result in different isoforms.

A25 frequencies

HLA A*2501 frequencies
		freq
ref.	Population	(%)
^[3]	Saudi Arabia	5.7
^[3]	India Jalpaiguri Toto	5.2
^[3]	Russia Northwest	5.0
^[3]	Spain Pas Valley	4.3
^[3]	Czech Republic	4.2
^[3]	Spain North Cantabrian	4.2
^[3]	Russia Arkhangelsk Pomors	4.0
^[3]	Croatia	3.9
^[3]	Spain North Cabuernigo	3.8
^[3]	Russia Chuvash	3.7
^[3]	Romanian	3.5
^[3]	Italy Bergamo	3.2
^[3]	Croatia	3.0
^[3]	Israel Ashkenazi Jews	2.8
^[3]	Bulgaria	2.7
^[3]	Spain Basque Arratia Valley	2.7
^[3]	Sweden Uppsala County	2.6
^[3]	Ireland Northern	2.1
^[3]	Turkey	2.1
^[3]	Wales	2.1
^[3]	Spain Eastern Andalusia	2.0
^[3]	Georgia Svaneti Svans	1.9
^[3]	Italy	1.9
^[3]	England Manchester	1.9
^[3]	England Lancaster	1.8
^[3]	Jews (Israel)	1.7
^[3]	Macedonia	1.7
^[3]	England Sheffield	1.6
^[3]	Portugal South pop2	1.4
^[3]	Italy South Campania	1.2
^[3]	Uganda Kampala	1.2
^[3]	Finland	1.1
^[3]	Portugal North	1.1
^[3]	Belgium	1.0
^[3]	France Corsica	1.0
^[3]	Mongolia Oold	1.0
^[3]	Russia Murmansk Saomi	1.0
^[3]	Tunisia	1.0
^[3]	France South East	0.8
^[3]	Morocco Nador Metalsa	0.7
^[3]	Greece	0.6
^[3]	Italy North Pavia	0.6
^[3]	Algeria	0.5
^[3]	China Qinghai Hui	0.5
^[3]	Guatemala Mayans	0.4
^[3]	Russia Nenets	0.4
^[3]	Cameroon Beti	0.3
^[3]	Beijing Shijiazhuang	0.1
^[3]	Taiwan Hakka	0.1

A*2501 distribution is primarily located in western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.

References

^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
^ derived from IMGT/HLA
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as ^at ^au ^av ^aw Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.

v • d • e HLA-A Serotypes
HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80

Category: HLA-A alleles

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A25". A list of authors is available in Wikipedia.