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Glycol cleavageGlycol cleavage is a specific type of organic chemistry oxidation. The carbon-carbon bond in a (vicinal diol (glycol) is cleaved and replaced with two carbon-oxygen double bonds. Depending on the substitution pattern in the diol, either ketones or aldehydes may be formed. Additional recommended knowledgeGlycol cleavage is an important reaction in the laboratory because it is useful for determining the structures of sugars. After cleavage takes place the ketone and aldehyde fragments can be inspected and the location of the former hydroxyl groups ascertained. ReagentsPeriodic acid (HIO4) and lead tetraacetate (Pb(OAc)4) are the most common reagents used for glycol cleavage. These reactions involve cyclic intermediates which then decompose to form ketones (if the R groups are not H) or aldehydes (if one of the R groups is H). Warm concentrated potassium permanganate (KMnO4) will react with an alkene to form a glycol and will then immediately cleave the glycol to give stable ketones or oxidizable aldehydes. The aldehydes will react further to become carboxylic acids. Controlling the temperature and concentration of the reagent can keep the reaction from continuing past the formation of the glycol. References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Glycol_cleavage". A list of authors is available in Wikipedia. |