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Glucosidases



Glucosidases are glycoside hydrolase enzymes categorized under the EC number 3.2.1.

Contents

Function

α-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen

They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.

Members

Different sources include different members in this class. Members marked with a "#" are considered by MeSH to be glucosidases.

Name EC Description
α-Amylase EC 3.2.1.1 is a digestive enzyme in mammals
β-Amylase EC 3.2.1.2 is a plant enzyme to break down starch
γ-Amylase EC 3.2.1.3 is a digestive enzyme
Cellulase # EC 3.2.1.4 breaks down cellulose from plant material
Sucrase-isomaltase EC 3.2.1.10 -
Acid α-glucosidase # EC 3.2.1.20 is associated with Glycogen storage disease type II
Beta-glucosidase # EC 3.2.1.21 - is associated with gaucher's disease
Lactase EC 3.2.1.23 one member of the β-galactosidase family, breaks down milk sugars, and its absence in adulthood causes lactose intolerance
Debranching enzyme # EC 3.2.1.33 -
Pullulanase EC 3.2.1.41 has been used as a detergent

Clinical significance

They are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type 2.

See also

  • DNA glycosylases
  • Mucopolysaccharidoses
v • d • e
Hydrolase: sugar hydrolases (EC 3.2)
3.2.1: Glycoside hydrolasesAmylase (Alpha-Amylase) - Chitinase - Lysozyme - Neuraminidase - Galactosidases (Alpha, Beta) - alpha-Mannosidase - Glucuronidase - Hyaluronidase - Pullulanase - Glucocerebrosidase - Galactosylceramidase - Alpha-N-acetylglucosaminidase - Fucosidase - Hexosaminidase - Iduronidase - Disaccharidase (Sucrase/Sucrase-isomaltase/Invertase, Maltase, Trehalase, Lactase) - Glucosidases (Cellulase, Alpha-glucosidase, Beta-glucosidase, Debranching enzyme)
3.2.2: Hydrolysing N-Glycosyl compoundsDNA glycosylases: Oxoguanine glycosylase
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Glucosidases". A list of authors is available in Wikipedia.
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