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Glucosidases

Glucosidases are glycoside hydrolase enzymes categorized under the EC number 3.2.1.

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1 Function
2 Members
3 Clinical significance
4 See also

Function

α-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen

They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.

Members

Different sources include different members in this class. Members marked with a "#" are considered by MeSH to be glucosidases.

Name	EC	Description
α-Amylase	EC 3.2.1.1	is a digestive enzyme in mammals
β-Amylase	EC 3.2.1.2	is a plant enzyme to break down starch
γ-Amylase	EC 3.2.1.3	is a digestive enzyme
Cellulase #	EC 3.2.1.4	breaks down cellulose from plant material
Sucrase-isomaltase	EC 3.2.1.10	-
Acid α-glucosidase #	EC 3.2.1.20	is associated with Glycogen storage disease type II
Beta-glucosidase #	EC 3.2.1.21	- is associated with gaucher's disease
Lactase	EC 3.2.1.23	one member of the β-galactosidase family, breaks down milk sugars, and its absence in adulthood causes lactose intolerance
Debranching enzyme #	EC 3.2.1.33	-
Pullulanase	EC 3.2.1.41	has been used as a detergent

Clinical significance

They are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type 2.

Amylase (Alpha-Amylase) - Chitinase - Lysozyme - Neuraminidase - Galactosidases (Alpha, Beta) - alpha-Mannosidase - Glucuronidase - Hyaluronidase - Pullulanase - Glucocerebrosidase - Galactosylceramidase - Alpha-N-acetylglucosaminidase - Fucosidase - Hexosaminidase - Iduronidase - Disaccharidase (Sucrase/Sucrase-isomaltase/Invertase, Maltase, Trehalase, Lactase) - Glucosidases (Cellulase, Alpha-glucosidase, Beta-glucosidase, Debranching enzyme)

3.2.2: Hydrolysing N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

Categories: Enzymes | Hydrolases | Carbohydrates | EC 3.2