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Gemeprost


Gemeprost
Systematic (IUPAC) name
methyl (E)-7-[(1R,2S,3R)-3-hydroxy-2- [(E,3R)-3-hydroxy-4,4-dimethyl-oct-1-enyl]- 5-oxo-cyclopentyl]hept-2-enoate
Identifiers
CAS number	64318-79-2
ATC code	G02AD03
PubChem	5282237
Chemical data
Formula	C₂₃H₃₈O₅
Mol. mass	394.545 g/mol
SMILES	search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Pessary

Gemeprost (16, 16-dimethyl-trans-delta2 PGE₁ methyl ester) is an analogue of prostaglandin E₁.

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Clinical use

In pessary form as the second drug in medical abortion regimen in the UK and Sweden. Gemeprost softens and dilates the cervix and stimulates the uterus to contract.

Side effects

Vaginal bleeding, cramps, nausea, vomiting, loose stools or diarrhea, headache, muscle weakness; dizziness; flushing; chills; backache; dyspnoea; chest pain; palpitations and mild pyrexia. Rare: Uterine rupture, severe hypotension, coronary spasms with subsequent myocardial infarctions.

Categories: Abortifacients | Prostaglandins