Fumonisin B1

Fumonisine B1 is an inhibitor of ceramide synthase.

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Fumonisin B1 is the most prevalent member of a family of toxins produced by several species of Fusarium moulds which occur mainly in maize. Fumonisin B1 contamination of maize has been reported worldwide at mg/kg levels. Human exposure occurs at levels of micrograms to milligrams per day and is greatest in regions where maize products are the dietary staple.

Fumonisin B1 is hepatotoxic and nephrotoxic in all animal species tested. The earliest histological change to appear in either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity of fumonisin is low, it is the known cause of two diseases which occur in domestic animals with rapid onset: equine leukoencephalomalacia and porcine pulmonary oedema syndrome. Both of these diseases involve disturbed sphingolipid metabolism and cardiovascular dysfunction.

References

• http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/212211.htm&word=leukoencephalomalacia