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Fructose 1,6-bisphosphate



Fructose 1,6-bisphosphate
Identifiers
CAS number 488-69-7
PubChem 172313
MeSH fructose-1,6-diphosphate
SMILES C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)OP(=O)(O)O
Properties
Molecular formula C6H14O12P2
Molar mass 340.116
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Fructose 1,6-phosphate is fructose sugar phosphorylated on carbons 1 and 6 (ie. is a fructosephosphate). The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-phosphate at some point.

Fructose 1,6-phosphate in glycolysis

Fructose 1,6-phosphate lies within the glycolysis metabolic pathway and is produced by phosphorylation of fructose 6-phosphate. It is in turn broken down into two compounds; glyceraldehyde 3-phosphate and glycerone phosphate. It is allosteric activator of pyruvate kinase.

β-D-fructose 6-phosphate 6-phosphofructo 1-kinase β-D-fructose 1,6-phosphate Fructose bisphosphate aldolase D-glyceraldehyde 3-phosphate dihydroxyacetone phosphate
+
ATP ADP
Pi H2O
Hexose diphosphatase Fructose bisphosphate aldolase

Compound C05345 at KEGG Pathway Database. Enzyme 2.7.1.11 at KEGG Pathway Database. Enzyme 3.1.3.11 at KEGG Pathway Database. Compound C05378 at KEGG Pathway Database. Enzyme 4.1.2.13 at KEGG Pathway Database. Compound C00111 at KEGG Pathway Database. Compound C00118 at KEGG Pathway Database.

The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

Fructose 1,6-phosphate isomerism

Main article: Fructose

Fructose 1,6-phosphate has only one biologically active isomer, the β-D-form. There are many other isomers, analogous to those of fructose.

See also

  • Fructose 2,6-bisphosphate
 v • d • e 
Glycolysis Metabolic Pathway
Glucose Hexokinase Glucose-6-phosphate Phosphoglucoisomerase Fructose 6-phosphate Phosphofructokinase Fructose 1,6-bisphosphate Fructose bisphosphate aldolase Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde phosphate dehydrogenase
ATP ADP ATP ADP NAD+ + Pi NADH + H+
+ 2
NAD+ + Pi NADH + H+
1,3-Bisphosphoglycerate Phosphoglycerate kinase 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Enolase Phosphoenolpyruvate Pyruvate kinase Pyruvate Pyruvate dehydrogenase Acetyl-CoA
ADP ATP H2O ADP ATP CoA + NAD+ NADH + H+ + CO2
2 2 2 2 2 2
ADP ATP H2O
This metabolism related chemical article is a stub. You can help Wikipedia by expanding it.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fructose_1,6-bisphosphate". A list of authors is available in Wikipedia.
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