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Fosfomycin


Fosfomycin
Systematic (IUPAC) name
[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
Identifiers
CAS number	23155-02-4 78964-85-9 (tromethamine)
ATC code	J01XX01
PubChem	446987
DrugBank	APRD00987
Chemical data
Formula	C₃H₇O₄P
Mol. mass	138.059 g/mol
Pharmacokinetic data
Bioavailability	30–37% (oral, fosfomycin tromethamine); varies with food intake
Protein binding	Nil
Metabolism	Nil
Half life	5.7 hours (mean)
Excretion	Renal and fecal, unchanged
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status	℞-only(US)
Routes	Oral

Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is indicated in the treatment of urinary tract infections. It is usually administered as fosfomycin tromethamine, trade name Monurol.

Additional recommended knowledge

Daily Visual Balance Check

Essential Laboratory Skills Guide

Correct Test Weight Handling Guide: 12 Practical Tips

Fosfomycin is usually administered as a single dose.

v • d • e Antibacterials for systemic use: others (J01X)
Glycopeptide	Vancomycin - Teicoplanin
Polymyxins	Colistin - Polymyxin B
Steroid antibacterials	Fusidic acid
Imidazole derivatives	Metronidazole - Tinidazole - Ornidazole
Nitrofuran derivatives	Nitrofurantoin - Nifurtoinol
Other	Fosfomycin - Xibornol - Clofoctol - Spectinomycin - Methenamine - Mandelic acid - Nitroxoline - Linezolid - Daptomycin - Hitachimycin - Dalbavancin - Telavancin