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Triamcinolone


Triamcinolone
Systematic (IUPAC) name
9-fluoro-11,16,17-trihydroxy-17- (2-hydroxyacetyl) -10,13-dimethyl-6,7,8,9,10,11,12, 13,14,15,16,17- dodecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number	124-94-7
ATC code	A01AC01 D07AB09, D07XB02, H02AB08, R01AD11, R03BA06, S01BA05
PubChem	31307
DrugBank	APRD00422
Chemical data
Formula	C₂₁H₂₇F O₆
Mol. mass	394.434 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	68%
Metabolism	Hepatic
Half life	88 minutes
Excretion	Fecal and renal
Therapeutic considerations
Pregnancy cat.	A (Au), C (US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, topical, IM, intra-articular, intrasynovial

Triamcinolone (trade names Kenalog, Aristocort, Nasacort, Tri-Nasal, Triderm, Azmacort, Trilone, Volon A, Tristoject, Fougera;) is a synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream.

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Uses

They are also used in the post-operative period of certain cosmetic surgery procedures, notably rhinoplasty. Injected into the subcutaneous area, they may help to alleviate stubborn swelling and decrease the presence of scar tissue.

Topical triamcinolone acetonide paste is often prescribed for mouth or gum irritation following dental procedures.

Triamcinolone is occasionally used to treat severe cases of hayfever.^[1]

Forms

Different triamcinolone salts are available, including acetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about 8 times as effective as prednisone.

References

^ Hayfever (allergic rhinitis) - BUPA

v • d • e Stomatological preparations (A01)
Caries prophylactic agents	Sodium fluoride - Sodium monofluorophosphate - Olaflur - Stannous fluoride
Anti-infectives and antiseptics	Hydrogen peroxide - Chlorhexidine - Amphotericin B - Polynoxylin - Domiphen - Oxyquinoline - Neomycin - Miconazole - Natamycin - Hexetidine - Tetracycline - Benzoxonium chloride - Tibezonium iodide - Mepartricin - Metronidazole - Clotrimazole - Sodium perborate - Chlortetracycline - Doxycycline - Minocycline - Eugenol
Corticosteroids	Triamcinolone - Dexamethasone - Hydrocortisone
Other	Epinephrine/Adrenalone - Benzydamine - Acetylsalicylic acid - Amlexanox

v • d • e Corticosteroids for systemic use (H02)
Mineralocorticoids	Aldosterone - Fludrocortisone - Desoxycortone
Glucocorticoids	Betamethasone - Dexamethasone - Fluocortolone - Methylprednisolone - Paramethasone - Prednisolone - Prednisone - Triamcinolone - Hydrocortisone - Cortisone - Prednylidene - Rimexolone - Deflazacort - Cloprednol - Meprednisone - Cortivazol
Anticorticosteroids	Trilostane

v • d • e Decongestants and other nasal preparations (R01)
Topical: sympathomimetics, plain	Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine
Topical: antiallergic agents, excluding corticosteroids	Cromoglicic acid - Levocabastine - Azelastine - Antazoline - Spaglumic acid - Thonzylamine - Nedocromil - Olopatadine
Topical: corticosteroids	Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone
Topical: other nasal preparations	Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin
Systemic use: Sympathomimetics	Phenylpropanolamine - Pseudoephedrine - Phenylephrine