Flutazolam

Flutazolam (Coreminal, MS-4101) is a drug which is a benzodiazepine derivative. It was invented in Japan, and this is the main country in which it has been used medically. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and is around the same potency as diazepam.^[1]

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Flutazolam is closely related in structure to another benzodiazepine, haloxazolam.^[2][3]

References

1. ^ Mitsushima T, Ueki S. Psychopharmacological effects of flutazolam (MS-4101). Nippon Yakurigaku Zasshi. 1978 Nov;74(8):959-79. (Japanese).
2. ^ Kuwayama T, Kurono Y, Muramatsu T, Yashiro T, Ikeda K. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution. Chemical and Pharmaceutical Bulletin (Tokyo). 1986 Jan;34(1):320-6.
3. ^ Yashiro T, Kuwayama T, Kawazura H, Suzuki T. The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system. Journal of the Pharmaceutical Society of Japan. 1987 Oct;107(10):830-4. (Japanese).