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Flibanserin


Flibanserin
Systematic (IUPAC) name
1-[2-[4-(3-trifluoromethyl phenyl) piperazin-1-yl] ethyl] benzimidazol- [1H]-2-one
Identifiers
CAS number	167933-07-5
ATC code	?
PubChem	?
Chemical data
Formula	C₂₀H₂₁F₃N₄O
Mol. mass	390.40 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Flibanserin^[1] is a drug produced by Boehringer Ingelheim. It is currently being investigated as a drug for women suffering from decreased sexual desire. It is a 5-HT1A serotonin receptor agonist and 5-HT2a serotonin receptor antagonist that had initially been developed as an anti-depressant.^[2]

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References

^ Borsini F, Evans K, Jason K, Rohde F, Alexander B, Pollentier S (summer 2002). "Pharmacology of flibanserin". CNS Drug Rev. 8 (2): 117-142.
^ Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R (Aug 2003). "Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors.". Br J Pharmacol. 139 (7): 1281-8.

Viagra for women?.
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain
Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety
Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain

Categories: Antidepressants | Piperazines