Fixed dose combination (antiretroviral)

Fixed dose combinations of antiretrovirals are multiple antiretroviral drugs combined into a single pill, which helps reduce pill burden. They may combine different classes of antiretrovirals or contain only a single class. Licensed fixed dose combinations are shown in the table below.

Brand Name	Drug Names (INN)	Date of FDA Approval	Company
Combivir®	zidovudine + lamivudine	September 26, 1997	GlaxoSmithKline
Trizivir®	abacavir + zidovudine + lamivudine	November 15, 2000	GlaxoSmithKline
Kaletra®	lopinavir + ritonavir	September 15, 2000	Abbott Laboratories
Epzicom® (in USA) Kivexa® (in Europe)	abacavir + lamivudine	August 2, 2004	GlaxoSmithKline
Truvada®	emtricitabine + tenofovir	August 2, 2004	Gilead Sciences
Atripla®	efavirenz + emtricitabine + tenofovir	July 12, 2006	Gilead Sciences and Bristol-Myers Squibb

v • d • e Antivirals used against HIV (HAART) (primarily J05)
Nucleoside & Nucleotide Reverse Transcriptase Inbitors (NRTI)	Abacavir (ABC) • Didanosine • Emtricitabine° • Lamivudine (3TC)° • Stavudine • Zidovudine (AZT)° • Tenofovir° • Apricitabine^† • Stampidine^† • Elvucitabine^† • Racivir^† • Zalcitabine^‡
Non-Nucleoside Reverse Transcriptase Inhibitiors (NNRTI)	Efavirenz° • Nevirapine • Etravirine^† • Rilpivirine^† • Loviride^‡ • Delavirdine^‡
Protease Inhibitors (PI)	Atazanavir • Darunavir • Fosamprenavir • Lopinavir° • Nelfinavir • Ritonavir • Saquinavir • Tipranavir • Amprenavir^‡ • Indinavir^‡
Entry/fusion inhibitors	Enfuvirtide • Maraviroc • Vicriviroc^† • PRO 140^†
Integrase inhibitors	Raltegravir • Elvitegravir^†
Maturation inhibitors	Bevirimat^† • Vivecon™^†
Combined formulations	Combivir • Atripla • Trizivir • Truvada • Kaletra • Epzicom
Other & experimental agents	Foscarnet • Synergistic enhancers • Epigallocatechin gallate • Portmanteau inhibitors • Globoidnan A • Griffithsin • Diarylpyrimidines • Calanolide A
^†Undergoing clinical trials, not FDA approved. ^‡Formerly or rarely used agent. °Preferred first-line agent.