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Fingolimod
Fingolimod (rINN, codenamed FTY720) is a novel immunosuppressant drug that causes lymphopenia by preventing egress of lymphocytes from lymph nodes. It is a sphingosine-1-phosphate receptor 1 modulator. Additional recommended knowledgeIt is a chemical modification of the Myriocin (ISP-1) metabolite of the fungus Isaria sinclairii (Dong Chong Xia Cao). It is a structural analogue of sphingosine and gets phosphorylated by sphingosine kinases in the cell (most importantly sphingosine kinase 2).[1][2] The molecular biology of this biological function lies in FTY720's activity at one of the five sphingosine-1-phosphate receptors, S1P1.[3]] It is currently in phase III clinical trials as monotherapy for relapsing-remitting multiple sclerosis.[4] In a previous phase III trial of kidney transplantation, FTY720 was found to be no better than the existing standard of care.[citation needed] See alsoReferences
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fingolimod". A list of authors is available in Wikipedia. |