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Feprosidnine


Feprosidnine
Systematic (IUPAC) name
5-Imino-3-(1-phenylpropan-2-yl)-5H-1,2,3-oxadiazol-3-ium-2-ide
Identifiers
CAS number	3441-64-3
ATC code	?
PubChem	72088
Chemical data
Formula	C₁₁H₁₃N₃O
Mol. mass	203.24 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Feprosidnine (Sydnophen) is a stimulant drug which was developed in the USSR in the 1970s.^[1]^[2] It is structurally related to another Russian drug mesocarb but unlike mesocarb it has not been developed for medical use in humans.

Additional recommended knowledge

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Sydnophen has multiple mechanisms of action, the relative importance of which has not been clearly established. Effects on the body include cholinergic,^[3] adrenergic,^[4] opioid^[5] and nitric oxide donating^[6] actions, all of which may contribute to its pharmacological effects to some extent.

Chemistry

Feprosidnine is a mesoionic sydnone imine.

References

^ Veksler IG, Riabukha VN, Balitskiĭ KP, Al'tshuler RA, Mashkovskiĭ MD. Immunostimulating and antitumor action of psychotropic preparations of the sydnonimine series. (Russian) Farmakologiia i Toksikologiia. 1980 May-Jun;43(3):349-52.
^ Koniaeva EI, Beketov AI. Effect of caffeine and sidnofen on the blood supply of the brain, kidneys and hindlimbs during antiorthostatism. (Russian) Farmakologiia i Toksikologiia 1987 May-Jun;50(3):39-42.
^ Samonina GE, Mandriko EV. Peripheral cholinolytic action--one of the effects of sidnofen. (Russian) Biulleten Eksperimental'noi Biologii i Meditsiny. 1989 Apr;107(4):449-51.
^ Babskaia NE. Sidnofen-dependent pre- and postsynaptic activation of peripheral adrenergic transmission. (Russian) Eksperimental'naia i Klinicheskaia Farmakologiia. 1992 Sep-Oct;55(5):21-5.
^ D'iakonova TL, Samonina GE. The naloxone-dependent effects of the psychostimulant sidnofen: a study on identified neurons of the snail. (Russian) Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova. 1994 Jul-Oct;44(4-5):786-95.
^ Arzamastsev AP, Severina IS, Grigor'ev NB, Granik VG. Exogenous donors of nitric oxide and inhibitors of NO-synthase (chemical aspects). (Russian). Vestnik Rossiiskoi Akademii Meditsinskikh Nauk. 2003;(12):88-95.

v • d • e Stimulants
Eugeroics	Adrafinil • Armodafinil • Carphedon • Modafinil
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Piperazines	BZP • MeOPP • MBZP • mCPP • 2C-B-BZP
Xanthines	Caffeine • Aminophylline • Paraxanthine • Theobromine • Theophylline
Tropanes	Brasofensine • CFT • Cocaethylene • Cocaine • Lometopane • RTI-121 • Tesofensine • Troparil
Cholinergics	Arecoline • Cotinine • Nicotine
Convulsants	Bicuculline • Gabazine • Pentetrazol • Picrotoxin • Strychnine • Thujone
Phenylaminooxazoles	4-Methyl-aminorex • Aminorex • Clominorex • Fenozolone • Fluminorex • Pemoline • Thozalinone
Others	Amineptine • Bemegride • BPAP • Clenbuterol • Clofenciclan • Cyclopentamine • Cyprodenate • Desoxypipradrol • Ethylphenidate • Ethamivan • Gilutensin • GYKI-52895 • Hexacyclonate • Indanorex • Indatraline • Isometheptene • Mazindol • MDPV • Mesocarb • Methylphenidate (Dexmethylphenidate) • Naphthylisopropylamine • Nikethamide • Nocaine • Nomifensine • Phacetoperane • Phthalimidopropiophenone • Pipradrol • Prolintane • Propylhexedrine • Pyrovalerone • Sibutramine • Tuamine • Vanoxerine • Yohimbine • Zylofuramine
See also Sympathomimetic amines

Category: Stimulants

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Feprosidnine". A list of authors is available in Wikipedia.