Fenproporex

Fenproporex (Perphoxene) is a stimulant drug which is used as an appetite suppressant. It is an amphetamine derivative which was developed in the 1960s and used for the treatment of obesity.^[1]

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Fenproporex produces amphetamine as a metabolite,^[2][3] and was withdrawn in many countries following problems with abuse,^[4] but it is still prescribed in some countries mainly in South America.

References

1. ^ Warembourg H, Jaillard J. Clinical experimentation with fenproporex in the treatment of obesity. Apropos of 40 cases. (French). Journal de la Faculte de medecine et de pharmacie de l'Universite de Lille. 1968 Mar;13(3):Suppl:273-6.
2. ^ Tognoni G, Morselli PL, Garattini S. Amphetamine concentrations in rat brain and human urine after fenproporex administration. European Journal of Pharmacology. 1972 Oct;20(1):125-6.
3. ^ Cody JT. Metabolic precursors to amphetamine and methamphetamine. Forensic Science Reviews 1993; 5:109.
4. ^ Pelissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, Giocanti D, Leonetti G. Abusive prescription of psychostimulants: a study of two cases. Journal of Forensic Science. 2006 Mar;51(2):407-10.