Felypressin

Felypressin is added to some local anaesthetics such as prilocaine in a concentration of 0.003 i.u./ml. Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone. Felypressin is a V1 Agonist, and will thus have affects at all V1 receptors. It will, however, have its main physiological effects on vascular SMC's due to the form in which it is administered.

Additional recommended knowledge

Safe Weighing Range Ensures Accurate Results

Essential Laboratory Skills Guide

What is the Correct Way to Check Repeatability in Balances?

V1 receptors are found in various sites around the body. The major points include the CNS, Liver, Anterior Pituitary, Muscle (both vascular and non-vascular smooth muscle), and Platelets (CLAMP).

Another example of a V1 Agonist is Terlipressin - which is used in Oesophageal Varices.

References

• "Vasopressin analogues and treatments", Prof Buckingham, ICSM - adapted by JHPatel