Erbin (protein)

Discovered in 1997, Erbin is a 200kDa protein containing a PDZ domain.^[1] Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis.^[2] Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.^[3]

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Erbin is named after its ability to bind ErbB2, though it shares a name with Saint Erbin, a 5th century Cornish monk. This has led some to suggest that Saint Erbin may be the patron saint of both PDZ domains and ErbB protein kinase receptors.

References

1. ^ Borg JP, Marchetto S. et al. (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell. Biol. 2 (7): 407-414. PMID 10878805.
2. ^ Kolch, W. (2003). "Erbin: sorting out ErbB2 receptors or giving Ras a break?". Sci. STKE. 199: pe37. PMID 12966186.
3. ^ Dai P, Xiong WC, and Mei L. (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex". J. Biol. Chem. 281 (2): 927-933. PMID 16301319.