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Eprosartan


Eprosartan
Systematic (IUPAC) name
4-[[2-butyl-5-(2-carboxy-3-thiophen-2-yl-prop-1-enyl)- imidazol-1-yl]methyl]benzoic acid
Identifiers
CAS number	133040-01-4
ATC code	C09CA02 ?
PubChem	9670
DrugBank	APRD00950
Chemical data
Formula	C₂₃H₂₄N₂O₄S
Mol. mass	Eprosartan mesylate: 520.625 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	5 to 9 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	?
Routes	Oral

Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. It is marketed as Teveten® by the Biovail Corporation in the United States and by Solvay Pharmaceuticals elsewhere. It is sometimes paired with hydrochlorothiazide.

Additional recommended knowledge

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Weighing the right way

The drug acts on the renin-angiotensin system in two ways to decrease total peripheral resistance. First, it blocks the binding of angiotensin II to AT₁ receptors in vascular smooth muscle, causing vascular dilatation. Second, it inhibits sympathetic norepinephrine production, further reducing blood pressure.

As with other angiotensin II receptor antagonists, eprosartan is generally better tolerated than enalapril (an ACE inhibitor), especially among the elderly.^[1]

References

^ Ruilope L, Jäger B, Prichard B (2001). "Eprosartan versus enalapril in elderly patients with hypertension: a double-blind, randomized trial". Blood Press. 10 (4): 223-9. PMID 11800061.

v • d • e Agents acting on the renin-angiotensin system (C09)
ACE inhibitors	Benazepril • Captopril • Enalapril • Fosinopril • Lisinopril • Perindopril • Quinapril • Ramipril • Spirapril • Trandolapril
Angiotensin II receptor antagonists (AIIRA)	Candesartan • Eprosartan • Irbesartan • Losartan • Olmesartan • Tasosartan • Telmisartan • Valsartan
Renin inhibitors	Aliskiren • Remikiren