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Ebastine


Ebastine
Systematic (IUPAC) name
4-(4-benzhydryloxy-1-piperidyl)-1- (4-tert-butylphenyl)butan-1-one
Identifiers
CAS number	90729-43-4
ATC code	R06AX22
PubChem	3191
Chemical data
Formula	C₃₂H₃₉N O₂
Mol. mass	469.658 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	Greater than 95%
Metabolism	Hepatic (CYP3A4-mediated), to carebastine
Half life	15 to 19 hours (carebastine)
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Ebastine (trade names Kestine, Evastin, Ebastel, Aleva) is a non-sedating H₁ antihistamine.

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It does not penetrate the blood-brain barrier and thus allows an effective block of the H₁ receptor in peripheral tissue without a central side effect, i.e not causing sedation or drowsiness.

v • d • e Antihistamines (primarily R06)
Aminoalkyl ethers	Bromazine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Olopatadine