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Drotaverine


Drotaverine
Systematic (IUPAC) name
(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7- diethoxy-3,4-dihydro-2H-isoquinoline
Identifiers
CAS number	985-12-6
ATC code	A03AD02
PubChem	1712095
Chemical data
Formula	C₂₄H₃₁N O₄
Mol. mass	397.507 g/mol
Pharmacokinetic data
Bioavailability	Highly variable
Protein binding	80 to 95%
Metabolism	Hepatic
Half life	7 to 12 hours
Excretion	Fecal and renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral, intravenous

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.

A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic.^[1] It has also been used to accelerate labor.^[2]

References

^ Romics I, Molnár DL, Timberg G, et al (2003). "The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones". BJU Int 92 (1): 92–6. doi:10.1046/j.1464-410X.2003.04262.x. PMID 12823389.
^ Singh KC, Jain P, Goel N, Saxena A (2004). "Drotaverine hydrochloride for augmentation of labor". Int J Gynaecol Obstet 84 (1): 17–22. PMID 14698825.