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Doripenem


Doripenem
Systematic (IUPAC) name
(4R,5S,6S)-6-(1-hydroxyethyl)-4-methyl-7-oxo-3- [(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl] sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Identifiers
CAS number	148016-81-3
ATC code	?
PubChem	73303
Chemical data
Formula	C₁₅H₂₄N₄O₆S₂
Mol. mass	420.50426 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Renal
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	IM, IV

Doripenem is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005. It is particularly active against Pseudomonas aeruginosa.

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Doripenem was approved by the United States Food and Drug Administration on October 12, 2007, to be sold under the tradename Doribax.^[1]

References

^ U.S. Food and Drug Administration (October 17 2007). "FDA Approves New Drug to Treat Complicated Urinary Tract and Intra-Abdominal Infections". Press release. Retrieved on 2007-10-25.

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - cephalosporins and related (J01D)
First generation	Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole
Second generation	Cefaclor, Cefamandole, Cefmetazole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime
Third generation	Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Latamoxef
Fourth generation	Cefepime, Cefpirome, Cefquinome
Other beta-lactam antibacterials	Monobactams (Aztreonam), Carbapenems (Meropenem, Ertapenem, Imipenem, Doripenem)