Divergent synthesis

In chemistry a divergent synthesis is a strategy with the aim to improve the efficiency of chemical synthesis. It is often an alternative to convergent synthesis or linear synthesis.

Additional recommended knowledge

How to quickly check pipettes?

How to ensure accurate weighing results every day?

Daily Sensitivity Test

In one strategy divergent synthesis aims to generate a library of chemical compounds by first reacting a molecule with a set of reactants. The next generation of compounds is generated by further reactions with each compound in generation 1. This methodology quickly diverges to large numbers of new compounds

• A generates A1, A2, A3, A4, A5 in generation 1
• A1 generates A11, A12, A13 in generation 2 and so on.

An entire library of new chemical compounds for instance sugars can be screened for desirable properties. In another strategy divergent synthesis starts from a molecule as a central core from which successive generations of building blocks are added. A good example is the divergent synthesis of dendrimers for example where in each generation new monomer reacts to the growing surface of the sphere.

Diversity oriented synthesis or (DOS) is a strategy for quick access to molecule libraries with an emphasis on skeletal diversity. In one such application ^[1] a Petasis reaction product (1) is functionalized with propargyl bromide leading to a starting compound (2) having 5 functional groups. This molecule can be subjected to whole set of reagents each reaction yielding a unique sketelon already in generation one ^[2].

References