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Dipeptidyl peptidase-4 inhibitors
Additional recommended knowledgeInhibitors of Dipeptidyl peptidase 4 , also DPP-4 inhibitors, are a new class of oral hypoglycemics which block DPP-4. Their mechanism of action is thought to result from increased Incretin levels (GLP-1 and GIP),[1][2][3] which, inhibit glucagon release (which increases the blood glucose) but more importantly increase insulin secretion and decrease gastric emptying. Drugs belonging to this class are vildagliptin[4], sitagliptin[5] and saxagliptin. Although extensive long-term, pre-clinical studies of the major DPP-4 inhibitors has failed to show any evidence of potential to cause tumors in laboratory animals, there was one in-vitro (i.e., test tube) study that has raised some questions. [6] References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dipeptidyl_peptidase-4_inhibitors". A list of authors is available in Wikipedia. |