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Dinoprostone


Dinoprostone
Systematic (IUPAC) name
7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] hept-5-enoic acid
Identifiers
CAS number	363-24-6
ATC code	G02AD02
PubChem	9691
DrugBank	APRD00927
Chemical data
Formula	C₂₀H₃₂O₅
Mol. mass	352.465 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

In medicine, dinoprostone, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour and also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.

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It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E₂ (by Pfizer Inc.) and Propess (by Ferring Pharmaceuticals), as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.

The chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid.

Like other prostaglandins, dinoprostone can be used as an abortifacient.

It works by binding and activating the prostaglandin E2 receptor.

v • d • e Eicosanoids: prostaglandins
Endogenous/series 2	D₂ - E₂ (Dinoprostone) - H₂ - I₂ (Prostacyclin)
Prostaglandin analogues	Alprostadil - Beraprost - Bimatoprost - Carboprost - Enprostil - Iloprost - Latanoprost - Misoprostol - Travoprost - Treprostinil